June 1, 2024

Pos0318 Single-Cell Transcriptomics Reveal Potent Extrafollicular B Cell Response Linked With Gzmk+ Cd8 T Cell Activation in Lupus Kidney

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XZXinliang ZhangUniversity of Electronic Science and Technology of China CWChangyou WuSun Yat-sen University ZCZetao ChenGuangzhou University of Chinese Medicine

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Implication

Observational study reveals intrarenal extrafollicular B cell expansion in lupus nephritis patients, highlighting pathogenic interactions with cytotoxic T cells.

Key Points

Accumulation of atypical memory b cells occurs across 6 active lupus nephritis biopsies, linking local antibody production to tissue pathology.
Assessment using single cell transcriptomics and repertoire sequencing mapped intrarenal lymphocytes across active cases and healthy controls.
Highlights an intrarenal extrafollicular b cell response driven by cd8 t cells, which may enable targeted therapeutic strategies in kidney disease.

Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e67075b6db6435875fb767 https://doi.org/10.1136/annrheumdis-2024-eular.1779

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Implication

Observational study reveals intrarenal extrafollicular B cell expansion in lupus nephritis patients, highlighting pathogenic interactions with cytotoxic T cells.

Pos0318 Single-Cell Transcriptomics Reveal Potent Extrafollicular B Cell Response Linked With Gzmk+ Cd8 T Cell Activation in Lupus Kidney

Discussion

Member takes

Implication

Key Points

Cite This Study

Pos0318 Single-Cell Transcriptomics Reveal Potent Extrafollicular B Cell Response Linked With Gzmk+ Cd8 T Cell Activation in Lupus Kidney

Discussion

Member takes

Implication

Key Points

Cite This Study

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