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August 20, 2025International Journal of CancerOpen Access

Genetic variants underlying precancerous conditions of hepatocellular carcinoma

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Authors

JGJonathan Jaime G. GuerreroPEPaolo C. EncarnacionMRMark Angelo S. del Rosario

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Overview

Review reveals genetic variants influence liver cancer risk in patients with hepatitis B and C, suggesting new prevention strategies.

Key Points

  • Genetic variants significantly influence the risk of developing hepatocellular carcinoma (HCC) in patients with chronic infections, highlighting the importance of genetic predispositions.
  • Key genetic factors like TP53 R249S, TERT mutations, and Wnt/B-catenin alterations play crucial roles in disease progression for those with chronic hepatitis B and C.
  • Observational review summarized genetic influences on precancerous liver conditions, particularly in populations affected by metabolic and alcohol-related diseases.
  • Identifying genetic risks and improving population-specific studies may enable more precise HCC prevention strategies, moving towards personalized medicine.

Cite This Study

Guerrero et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd3ad7bf08b1ead5ffehttps://doi.org/10.1002/ijc.70092
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