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August 20, 2025Precision Clinical MedicineOpen Access

Molecular Mechanisms and Genetic Features of Cholangiocarcinoma: Implications for Targeted Therapeutic Strategies

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Authors

XLXiao LuSXShoujia XuZDZhe Deng

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Overview

Review reveals key mechanisms of therapeutic resistance in cholangiocarcinoma, highlighting implications for targeted treatments.

Key Points

  • Cholangiocarcinoma presents significant therapeutic challenges due to its aggressive nature and response to treatment.
  • Approximately 15% of liver cancers are cholangiocarcinoma, yet it often presents at advanced stages, complicating treatment strategies.
  • The review synthesizes genomic and epigenetic mechanisms underpinning cholangiocarcinoma, providing insights on targeted therapies.
  • Emphasis is placed on overcoming therapeutic resistance to enhance biomarker-driven precision medicine in cholangiocarcinoma.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd8ad7bf08b1ead625chttps://doi.org/10.1093/pcmedi/pbaf021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cholangiocarcinoma: Recent Advances in Molecular Pathobiology and Therapeutic Approaches2024 · 44 citations
  2. 2Novel Approach In Treatment of Cholangiocarcinoma: A Review2025
  3. 3Diagnosis and Management of Cholangiocarcinoma (CCA)2025
  4. 4Modern therapeutic approaches in cholangiocarcinoma: A narrative review of key biomarkers and clinical trials2026 · 1 citations
  5. 5Current Status of Drug Treatment of Cholangiocarcinoma—Updated Progress and Critical Limitations2026 · 1 citations