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August 20, 2025Clinical and Experimental Dermatology

Management of advanced basal cell carcinoma with hedgehog inhibitors: a real-world prospective comparative study

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Authors

FVFederico VenturiBZBiancamaria ZuccaroGPGabriella Perillo

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Overview

Prospective study reports higher efficacy of sonidegib over vismodegib in patients with advanced BCC, indicating improved treatment protocols.

Key Points

  • Sonidegib shows an overall response rate of 89.5%, surpassing vismodegib's 60.6% in treating advanced BCC.
  • Among vismodegib-treated patients, 27.5% achieved complete response, while sonidegib had a complete response rate of 36.8%.
  • This prospective study, conducted over 10 years in Italy, included 66 patients and collected extensive efficacy and safety data.
  • Findings suggest that changing treatment from vismodegib to sonidegib maintains effectiveness, highlighting potential for future management strategies.

Cite This Study

Venturi et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd8ad7bf08b1ead63afhttps://doi.org/10.1093/ced/llaf383
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