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October 8, 2025BMC CancerOpen Access

Vismodegib treatment in locally advanced basal cell carcinoma limited to the facial region: a single-center experience

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Authors

İGİvo GökmenEŞErdem Şen

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Overview

Retrospective study reports high efficacy of vismodegib in locally advanced basal cell carcinoma patients, suggesting careful safety monitoring for adverse events.

Key Points

  • Vismodegib treatment resulted in a high overall objective response rate of 89.3% among patients with locally advanced basal cell carcinoma.
  • The median progression-free survival was reported at 15.1 months, highlighting the treatment's effectiveness in managing this condition.
  • Adverse events were noted in 78.6% of patients, with dysgeusia and muscle spasms being the most common side effects.
  • Long-term vismodegib therapy increased the incidence of adverse events, indicating a need for continuous safety monitoring.

Cite This Study

Gökmen et al. (2025) studied this question.

synapsesocial.com/papers/68e6679587ecc93a24d17466https://doi.org/10.1186/s12885-025-14914-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Safety and Efficacy of Vismodegib and Sonidegib in Advanced Basal Cell Carcinoma of the Head and Neck: A Systematic Review and Meta‐Analysis2025
  2. 2Real-World Treatment Patterns of Patients with Basal Cell Carcinoma Using Sonidegib and Vismodegib2025
  3. 3Clinical Outcomes of Sonidegib in Vismodegib‐Exposed Locally Advanced Basal Cell Carcinoma: Insights From a Multicenter Descriptive Study2026
  4. 4Phase II, Single-Arm Trial of Induction and Concurrent Vismodegib With Curative-Intent Radiation Therapy for Locally Advanced, Unresectable Basal Cell Carcinoma2024 · 10 citations
  5. 5Management of Locally Advanced Basal Cell Carcinoma with Sonic Hedgehog Pathway Targeted Therapy: A Case Report and Discussion2024 · 1 citations