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February 9, 2026Journal of Skin CancerOpen Access

Clinical Outcomes of Sonidegib in Vismodegib‐Exposed Locally Advanced Basal Cell Carcinoma: Insights From a Multicenter Descriptive Study

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Authors

APAlvaro Prados-CarmonaMMMaría Martínez-PérezJVJ. Pablo Velasco-Amador

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Overview

Observational study evaluates sonidegib effectiveness in previously treated basal cell carcinoma, suggesting second-line potential.

Key Points

  • To evaluate the clinical outcomes of sonidegib in patients with locally advanced basal cell carcinoma previously treated with vismodegib.
  • Multicenter, descriptive, observational study design
  • Retrospective analysis of twelve patients with aggressive locally advanced basal cell carcinoma
  • Patients had prior treatment with vismodegib for at least 3 months
  • Treatment response classified based on tumor size changes
  • Adverse events documented and managed
  • Two patients achieved complete clinical response
  • Nine patients demonstrated partial response
  • One patient exhibited disease progression
  • Disease control was achieved in 11 of 12 patients (91.7%)
  • No novel adverse events were documented

Cite This Study

Prados-Carmona et al. (2026) studied this question.

synapsesocial.com/papers/69897a86f0ec2af6756e8abfhttps://doi.org/10.1155/jskc/9016298
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Management of advanced basal cell carcinoma with hedgehog inhibitors: a real-world prospective comparative study2025
  2. 2Real-World Treatment Patterns of Patients with Basal Cell Carcinoma Using Sonidegib and Vismodegib2025
  3. 3Sonidegib: Real-life experience with Hedgehog inhibitor for the treatment of locally advanced basal cell carcinoma2024
  4. 4Vismodegib treatment in locally advanced basal cell carcinoma limited to the facial region: a single-center experience2025
  5. 5Hedgehog pathway inhibitors for locally advanced and metastatic basal cell carcinoma: A real-world single-center retrospective review2024 · 9 citations