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April 27, 2026Clinical and Experimental Dermatology

Real-world efficacy and safety of Sonidegib in Locally Advanced and Multiple Basal Cell Carcinomas: A Monocentric Prospective Observational Study

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Authors

CRChiara Del ReVFVincenzo FILASTROGFGaia Fasano

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Overview

Monocentric study evaluates efficacy and safety of Sonidegib in patients with advanced basal cell carcinomas, suggesting its therapeutic value.

Key Points

  • This study aims to assess the real-world efficacy and safety of Sonidegib in treating locally advanced and multiple basal cell carcinomas.
  • Monocentric prospective observational design
  • Involved 17 patients with complex surgical histories and comorbidities
  • Evaluated objective response rates and safety over a mean treatment duration of 7.3 months
  • Objective response rate was 52.9% with 29.4% achieving partial response and 17.7% stable disease
  • Sonidegib led to a mean reduction of 3.89 lesions per patient
  • The safety profile was favorable with predominantly mild adverse events

Cite This Study

Re et al. (2026) studied this question.

synapsesocial.com/papers/69eefcf4fede9185760d3c36https://doi.org/10.1093/ced/llag157
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