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August 20, 2025PharmaceuticalsOpen Access

Neuromuscular System of Nematodes Is a Target of Synergistic Pharmacological Effects of Carvacrol and Geraniol

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Authors

MSMaja StojkovićDMDjordje S. MarjanovićDMDragana Medić

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Overview

Observational analysis revealed synergistic antinematodal effects in nematodes, suggesting new drug potentials.

Key Points

  • The combination of carvacrol and geraniol reduced the LC50 values by nearly 10-fold in C. elegans, indicating enhanced nematocidal effects.
  • Geraniol and carvacrol inhibited contractions in Ascaris suum, significantly increasing the EC50 of ACh, impacting neuromuscular function.
  • Effects of these monoterpenes on the ACR-16 nicotinic acetylcholine receptor showed decreased maximum current in Xenopus oocytes, highlighting interaction dynamics.
  • Understanding these interactions supports the development of new antiparasitic therapies using essential plant oil components.

Cite This Study

Stojković et al. (2025) studied this question.

synapsesocial.com/papers/68af4cdfad7bf08b1ead67e4https://doi.org/10.3390/ph18081232
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EFFECTS OF MENTHOL AND MONEPANTEL ON THE CONTRACTIONS OF THE ISOLATED NEUROMUSCULAR PREPARATION OF ASCARIS SUUM2024
  2. 2Comparative Study of the Effects of Carvacrol and p-Cymene on the Motor Activity of Rats and Movement of Caenorhabditis elegans2026
  3. 3Unlocking the Antiparasitic Potential of Apiaceae: The Promise of Geraniol for Scabies Treatment2024
  4. 4Control of citrus nematode Tylenchulus semipenetrans (Tylenchida: Tylenchulidae) using plant-based products under in vitro and in vivo conditions2024 · 1 citations
  5. 5Nematicidal trans-Anethole Blends Paralyzing Meloidogyne incognita2024 · 1 citations