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April 1, 2026MoleculesOpen Access

Comparative Study of the Effects of Carvacrol and p-Cymene on the Motor Activity of Rats and Movement of Caenorhabditis elegans

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Authors

OSOliver StošićDMDragana MedićDMDjordje S. Marjanović

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Overview

Comparative study shows carvacrol and p-cymene affect motor activity and toxicity in rats and C. elegans, suggesting differential impacts.

Key Points

  • The study aims to compare the toxic effects of carvacrol and p-cymene on motor activity in rats and movement in C. elegans.
  • Investigated acute toxicity of carvacrol and p-cymene in rats and C. elegans.
  • Administered varying concentrations of these compounds for 28 days to assess CNS effects.
  • Measured LD50 and LC50 values for both substances to determine toxicity levels.
  • Calculated LD50 for carvacrol at 790.15 mg/kg and for p-cymene above 3000 mg/kg indicating lower toxicity of p-cymene.
  • Carvacrol affected C. elegans reproduction and movement at lower concentrations than p-cymene.
  • While less toxic, p-cymene increased rolling behavior in C. elegans, suggesting potential issues with motility.

Cite This Study

Stošić et al. (2026) studied this question.

synapsesocial.com/papers/69ccb63f16edfba7beb87efchttps://doi.org/10.3390/molecules31071119
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