Comparative analysis shows discrepancies between in vitro sensitivity and clinical efficacy in chronic tonsillitis, indicating antibiotic resistance is a rising concern.
The rise in antibiotic resistance of Streptococcus pyogenes in chronic tonsillitis remains a global issue, exacerbated by irrational use of antibacterial drugs, low patient adherence to therapy, and the spread of resistant strains. Of particular concern is the discrepancy between the relatively high in vitro sensitivity of microorganisms and the reduced clinical efficacy of drugs in vivo, which requires an in-depth analysis of the causes of such disparities.
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Burenkov et al. (2025) studied this question.
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