Diagnostic Accuracy of Serum Procalcitonin (PCT) as an Early Biomarker of Neonatal Sepsis using Blood Culture as Gold Standard: A Prospective Study

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Discussion

Prospective study demonstrates high sensitivity and predictive value of serum pct in diagnosing neonatal sepsis.

Serum procalcitonin showed high sensitivity of 92.0% for diagnosing neonatal sepsis, indicating reliability as a biomarker.
Specificity for pct was recorded at 83.3%, surpassing traditional blood culture methods in emerging diagnostic options.
Observational analysis across a cohort of 61 neonates revealed that pct levels were significantly elevated in cases with positive blood cultures.
High negative predictive value of 93.8% underscores the potential of pct in ruling out neonatal infections effectively.

Nabi et al. (2025) studied this question.

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