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This is a Human Clinical Trial study (also classified as: Observational).

August 21, 2025AJP Regulatory Integrative and Comparative PhysiologyOpen Access

The Efficacy of Foot and Neck Cooling on Autophagy and Cellular Stress Responses in Peripheral Blood Mononuclear Cells from Older Adults Exposed to Extreme Heat

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Foot and neck cooling strategies improve autophagic responses during extreme heat exposure for older adults.
Increased p62 concentrations in control group highlight the protective effects of cooling methods on cellular stress.
We conducted a controlled trial assessing cellular changes in participants during heated conditions at 38°C.
These findings indicate potential adaptive mechanisms against heat-related cellular stress in vulnerable populations.

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Implication

Cooling methods enhance autophagy in peripheral blood mononuclear cells from older adults exposed to extreme heat, suggesting potential benefits for at-risk populations.

Cite This Study

McCormick et al. (2025) studied this question.

synapsesocial.com/papers/68af5095ad7bf08b1ead828d https://doi.org/10.1152/ajpregu.00110.2025

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Implication

Cooling methods enhance autophagy in peripheral blood mononuclear cells from older adults exposed to extreme heat, suggesting potential benefits for at-risk populations.

The Efficacy of Foot and Neck Cooling on Autophagy and Cellular Stress Responses in Peripheral Blood Mononuclear Cells from Older Adults Exposed to Extreme Heat

Key Points

Discussion

Implication

Cite This Study

The Efficacy of Foot and Neck Cooling on Autophagy and Cellular Stress Responses in Peripheral Blood Mononuclear Cells from Older Adults Exposed to Extreme Heat

Key Points

Discussion

Implication

Cite This Study

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