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August 21, 2025Open Access

Unveiling the Prognostic Significance and Immunological Characteristics of T Cell Marked Ubiquitination Related Genes in Colorectal Adenocarcinoma via Single-Cell and bulk RNA Sequencing

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Authors

RYRuanruan YangLHLuji HuangXLXiaoling Liao

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Overview

Single-cell sequencing identifies T cell genes impacting prognosis and immune microenvironment in colorectal adenocarcinoma, suggesting targeted therapies.

Key Points

  • T cell marked ubiquitination related genes significantly impact prognosis and immune profiles in colorectal adenocarcinoma, indicating a need for personalized treatment.
  • Seven distinct T cell marked ubiquitination related genes were identified, revealing two molecular subtypes distinguished by biological behavior in immune microenvironment.
  • Utilizing multi-omics and machine learning methods, a risk-prognostic model was developed which highlights key gene influences on patient outcomes in colorectal adenocarcinoma.
  • Immune microenvironment analysis suggests high-risk patients may face poorer outcomes, supporting targeted therapies for low-risk patients, predicted based on drug sensitivity analysis.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68af5095ad7bf08b1ead84d8https://doi.org/10.21203/rs.3.rs-6659774/v1
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