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August 15, 2025Frontiers in PharmacologyOpen Access

Identification of biomarkers based on ubiquitin-correlated genes for predicting immune profile and drug sensitivity in lung adenocarcinoma

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Authors

YLYue LiWTWei TianCCChen Chen

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Overview

Analysis uncovers biomarkers predicting immune profile and drug sensitivity in lung adenocarcinoma, indicating novel diagnostic opportunities.

Key Points

  • High-risk lung adenocarcinoma patients show significantly lower overall survival and altered immune profiles.
  • 197 intersected genes identified through WGCNA, with 32 found to be associated with prognosis for risk modeling.
  • Method utilized involves univariate and multifactorial Cox regression analyses to refine the gene selection.
  • Findings support a new risk model integrating the ubiquitin pathway, highlighting potential diagnostic biomarkers.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af50a1ad7bf08b1ead8bc4https://doi.org/10.3389/fphar.2025.1646396
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