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August 15, 2025ACS Applied Nano MaterialsOpen Access

Cancer Cell Membrane-Wrapped Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Triple-Negative Breast Cancer

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Authors

SASara B. AboeleneenGAG. de M. AzevedoKLKejian Li

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Overview

In vitro analysis reveals improved tumor targeting and imaging with nanoparticles coated in cancer cell membranes, suggesting enhanced treatment effectiveness.

Key Points

  • Significantly enhances photoacoustic imaging signals by about 7X in tumors compared to conventional nanoparticles, indicating better imaging capabilities.
  • Photothermal therapy using these nanoparticles reduces tumor growth by approximately 1.7X and increases apoptosis by 1.8X, pointing to effective tumor mitigation.
  • Silica core/gold shell nanoshells wrapped with TNBC cell membranes exhibit promising homotypic recognition for improved treatment outcomes.
  • These findings support the continued development of tailored therapies that may improve prognosis for challenging breast cancer subtypes.

Cite This Study

Aboeleneen et al. (2025) studied this question.

synapsesocial.com/papers/68af509bad7bf08b1ead878ehttps://doi.org/10.1021/acsanm.5c03543
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