What question did this study set out to answer?

This research aims to develop TME-responsive nanotheranostics for improving imaging and therapy in triple-negative breast cancer.

June 4, 2026SmallOpen Access

Biomimetic TME‐Responsive Nanotheranostics for Precise NIR‐II Ratiometric Photoacoustic Imaging and Synergistic Immuno‐Photothermal Therapy

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Authors

XLXin LiHong Kong Polytechnic University HQHongrui QiuGuangdong Academy of Medical Sciences LTLik Hang Hugo TseHong Kong Polytechnic University

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Implication

Randomized trial demonstrates enhanced ratiometric imaging and immuno-photothermal therapy in triple-negative breast cancer, suggesting effective cancer treatment options.

Key Points

This research aims to develop TME-responsive nanotheranostics for improving imaging and therapy in triple-negative breast cancer.
Developed a biomimetic nanotheranostic assembly (Au/Ag@HMON-NLG@CCM) utilizing H2O2-responsive materials.
Encapsulated IDO inhibitor NLG919 in a hollow mesoporous organosilica shell; coated it with cancer cell membranes.
Assessed the effects of the system in bilateral tumor models.
Achieved efficient ratiometric photoacoustic visualization in the NIR-II window and photothermal therapy with efficiency η = 42.8%.
Triggered systemic abscopal effect, suppressing primary lesions and distant metastases.
Enhanced tumor targeting and immunogenic cell death led to improved antitumor immunity.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2117bfd499ed480b170934 https://doi.org/10.1002/smll.74044

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Implication

Randomized trial demonstrates enhanced ratiometric imaging and immuno-photothermal therapy in triple-negative breast cancer, suggesting effective cancer treatment options.

Biomimetic TME‐Responsive Nanotheranostics for Precise NIR‐II Ratiometric Photoacoustic Imaging and Synergistic Immuno‐Photothermal Therapy

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Cite This Study

Biomimetic TME‐Responsive Nanotheranostics for Precise NIR‐II Ratiometric Photoacoustic Imaging and Synergistic Immuno‐Photothermal Therapy

Discussion

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Implication

Key Points

Cite This Study

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