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August 15, 2025Frontiers in NeurologyOpen Access

Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment

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Authors

YYYoungSoon YangMKMin‐Seong KooYKYong Tae Kwak

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Overview

Retrospective cohort study shows Ginkgo biloba improves cognition in amyloid PET-positive patients, indicating potential disease-modifying effects.

Key Points

  • Ginkgo biloba significantly improved cognition and daily functioning in patients after 12 months, without conversions to Alzheimer’s disease.
  • Responder rates were higher in the Ginkgo group (100% vs. 59.1%), demonstrating meaningful clinical improvements in cognitive assessments.
  • This analysis involved 64 amyloid PET-positive MCI patients, evaluating outcomes between Ginkgo biloba monotherapy and standard cognitive enhancers.
  • Results indicate a potential reduction in plasma Aβ oligomerization, suggesting disease-modifying effects that need further validation in trials.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68af509bad7bf08b1ead87behttps://doi.org/10.3389/fneur.2025.1639924
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ginkgo biloba and longitudinal changes in amyloid PET and plasma amyloid-β oligomerization in amyloid-positive mild cognitive impairment: A retrospective analysis2026 · 1 citations
  2. 2Associations of Ginkgo biloba extract exposure with 12-month cognitive trajectories in amyloid PET–positive mild cognitive impairment and Alzheimer’s disease: a pooled retrospective cohort study2026
  3. 3Ginkgo Biloba for Alzheimer’s Disease: From Mixed Dementia Trials to Biomarker-Confirmed Mild Cognitive Impairment—What Have We Learned over Two Decades, and Is There Finally a Bit of Hope?2026
  4. 4Efficacy of Standardized Ginkgo biloba Extract in Cognitive Enhancement for Alzheimer’s patients2025 · 1 citations
  5. 5Combined treatment with <i>Ginkgo biloba</i> extract EGb 761 plus acetylcholinesterase inhibitors improved cognitive function and neuropsychiatric symptoms in patients with mild cognitive impairment2022 · 10 citations