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January 1, 2022Alzheimer s & Dementia Translational Research & Clinical InterventionsOpen Access

Combined treatment with Ginkgo biloba extract EGb 761 plus acetylcholinesterase inhibitors improved cognitive function and neuropsychiatric symptoms in patients with mild cognitive impairment

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Authors

JGJosé María García‐AlbercaInstituto de Salud Carlos IIIEGEsther GrisInstituto de NeurocienciasSMSilvia MendozaInstituto de Neurociencias

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Overview

Retrospective cohort study shows enhanced cognitive and behavioral outcomes from combined EGb 761 and acetylcholinesterase inhibitors in mild cognitive impairment, suggesting synergistic benefits.

Key Points

  • To evaluate the potential synergistic therapeutic effects of combining Ginkgo biloba extract EGb 761 with acetylcholinesterase inhibitors in patients with amnestic mild cognitive impairment in routine clinical practice.
  • Retrospectively evaluated 133 memory clinic patients with amnestic mild cognitive impairment across three groups: EGb 761 monotherapy, AChEI monotherapy (donepezil, galantamine, or rivastigmine), or EGb 761 plus AChEI combination therapy.
  • Assessed cognitive, functional, and behavioral endpoints—including MMSE, RAVLT, TMT Parts A and B, CFT, and NPI—over a 12-month follow-up period using mixed-effects model analysis.
  • After 12 months, combination therapy with EGb 761 plus AChEI showed statistically significant improvements in MMSE, RAVLT, CFT, TMT A–B, and NPI compared with AChEI monotherapy.
  • Combination therapy demonstrated significant superiority over EGb 761 monotherapy on the MMSE and RAVLT at 12 months.
  • EGb 761 monotherapy achieved superior outcomes compared to AChEI monotherapy on CFT, TMT A–B, and NPI at 12 months.

Cite This Study

García‐Alberca et al. (2022) studied this question.

synapsesocial.com/papers/6a7154d4febe604dd70a03dehttps://doi.org/10.1002/trc2.12338
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Meta-analysis of Ginkgo biloba extract EGb 761 in the treatment of mild dementia2025
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