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August 15, 2025PharmaceuticalsOpen Access

Discovery and Evaluation of Novel Sulfonamide Derivatives Targeting Aromatase in ER+ Breast Cancer

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Authors

BFBarbara De FilippisMAMariangela AgamennoneAAAlessandra Ammazzalorso

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Overview

Evaluation reveals sulfonamide compounds effectively inhibit aromatase in breast cancer, suggesting multi-target strategies may enhance therapy.

Key Points

  • Compounds 3 and 9 show significant aromatase inhibition and cytotoxicity against MCF7 breast cancer cells, outperforming previous inhibitors.
  • The study reports IC50 values in the low micromolar range, indicating these compounds are potent and selective.
  • Molecular docking and dynamic simulations confirm stable binding interactions with the aromatase enzyme.
  • Target fishing identified EGFR and PTK2B as potential targets for enhancing the therapeutic approach in breast cancer.

Cite This Study

Filippis et al. (2025) studied this question.

synapsesocial.com/papers/68af50a1ad7bf08b1ead8af2https://doi.org/10.3390/ph18081206
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure‐Guided Identification of Novel Aromatase Inhibitors Targeting Breast Carcinoma2024 · 1 citations
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  3. 3An integrated computational, in vitro and metabolomics approach to the discovery of novel aromatase inhibitors with anti-breast cancer activities2025
  4. 4Design, Synthesis and Molecular Modeling Studies of Triazole Derivatives as Aromatase İnhibitors2026
  5. 5Design and Synthesis of New Triazol Derivatives as Aromatase Enzyme Inhibitors2026 · 1 citations