August 15, 2025Frontiers in ImmunologyOpen Access

Editorial: Unveiling the host’s acute immune response to infectious mucosal diseases: insights and implications

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Editorial discusses innate immunity's role in infection and tissue modulation, highlighting key mechanisms in disease response.

Key findings reveal activated monocyte subsets play a crucial role in shaping immune responses during bacterial infections, enhancing innate immunity.
The editorial emphasizes the role of TLR9 in red blood cells, linking mitochondrial DNA to immune responses, indicating a broader function beyond traditional views.
Assessment of how mucosal administration of LPS could beneficially modulate immune responses suggests potential therapeutic avenues in infectious diseases.
Importance of IL-22 in neonatal immune development underscores the relevance of early-life cytokines in maintaining mucosal barrier integrity and overall health.

Arish et al. (2025) studied this question.

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