August 15, 2025DiseasesOpen Access

PIEZO Channels in Mechano-Inflammation: Gatekeepers of Neuroimmune Crosstalk

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Discussion

This review highlights the impact of piezo channels on inflammation and pain in neuroimmune responses, suggesting therapeutic targets.

Piezo channels are critical in mediating immune responses, influencing inflammation and pain sensitivity.
Evidence shows that piezo1 regulates calcium-dependent pro-inflammatory pathways, affecting immune cell function.
Comprehensive narrative synthesis covered experimental studies linking piezo channels with various inflammatory processes.
The findings highlight piezo channels as potential targets for new therapies in mechano-inflammation-related conditions.

Carmelo Pirri (2025) studied this question.

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