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June 14, 2026Frontiers in ImmunologyOpen Access

Piezo1 in immune cells: from mechanosensation to immunoregulation

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Authors

YLYuling LiangQCQiuxia ChenSZShuqiao Zhang

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Overview

Review integrates evidence on Piezo1's role in immune cell processes, suggesting implications for immunotherapy.

Key Points

  • To analyze the role of Piezo1 in immune cells and its effects on immune processes.
  • Systematic review of research studies concerning Piezo1 in immune cells.
  • Analysis of Piezo1's involvement in immune cell activation, differentiation, and regulation.
  • Piezo1 is crucial for cell activation and functional regulation in immune cells.
  • Context-dependent signaling of Piezo1 drives varied immune outcomes based on cell type and environment.
  • The findings emphasize Piezo1's dual role, offering insights for precision immunotherapy development.

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4429b1cc60ccdea8a11ehttps://doi.org/10.3389/fimmu.2026.1827414
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Also Consider

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  1. 1Piezo1 in the central nervous system: decoding the mechanical signature of neuroinflammation.2026 · 2 citations
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  3. 3PIEZO Channels in Mechano-Inflammation: Gatekeepers of Neuroimmune Crosstalk2025
  4. 4The dual role of Piezo1 in tumor cells and immune cells: a new target for cancer therapy2025 · 24 citations
  5. 5Mechanical Regulation of the Immune System: From Sensory Mechanisms to Disease Pathogenesis2026 · 1 citations