Cross-sectional study found WT1 immunoexpression links with aggressive features in colorectal adenocarcinoma, suggesting its significance as a prognostic marker.
Background: Wilms Tumor 1 (WT1) is a transcription factor involved in cellular proliferation and differentiation, with emerging relevance in various malignancies including colorectal adenocarcinoma (CRC). The aim of this study was to assess the immunohistochemical expression of WT1 in colorectal adenocarcinoma and determine its association with age, gender, histological type, grade, stage, lymphovascular invasion (LVI), and perineural invasion (PNI). Methods:This cross-sectional observational study included 97 histopathologically diagnosed cases of colorectal adenocarcinoma, selected using purposive sampling. The study was conducted at the Department of Pathology, Dhaka Medical College Hospital, while WT1 immunohistochemistry was performed at the Immunohistochemistry Laboratory of Bangladesh Medical University, Dhaka. The study duration was from March 2021 to February 2025. Qualitative data were expressed as frequency and percentage. The Chi- square and Fisher’s exact test were used to assess the relation between qualitative variables. A p-value less than 0.05 were considered as significant. Results:Among 97 cases, 55% showed low and 45% showed high WT1 expression. High WT1 expression was significantly associated with mucinous type (p=0.0214), poorly differentiated tumors (p=0.0012), and advanced pathological T (p=0.0007) and N stages (p=0.0003). No significant association was observed with age, gender, LVI, or PNI. Conclusion: WT1 immunoexpression associates with aggressive histopathological features in colorectal adenocarcinoma, suggesting its potential role as a prognostic marker.
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Nupur et al. (2025) studied this question.
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