Case report details heterotopic ossification in the gallbladder of an 18-year-old girl, indicating chronic inflammation may contribute.
Heterotopic ossification in the gall bladder is a rare condition, with few reported cases. Its pathogenesis remains unclear, though chronic inflammation may predispose to the condition. An 18-year-old girl underwent laparoscopic cholecystectomy due to persistent upper quadrant pain, nausea, and postprandial vomiting. Preoperative ultrasound revealed a polyp with features of cholecystitis. The post-operative course was uneventful. Histopathological examination showed fibromuscular hyperplasia, infiltration of chronic inflammatory cells, including foamy histiocytes, in the lamina propria. Rokitansky–Aschoff sinuses were present. The polypoid area exhibited denuded epithelium, mature bone formation, and marrow elements without evidence of metaplasia, dysplasia or malignancy.
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Anjum et al. (2025) studied this question.
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