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August 22, 2025Transplantation DirectOpen Access

Sex- and Age-based Comparison of Key Clinical Markers of Immunity After Heart and Kidney Transplantation

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Authors

WPWhitney PerryJCJennifer ChowAMAudrey Martino

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Overview

Observational analysis revealed significant differences in immunity markers among postmenopausal organ transplant recipients, suggesting increased infection risk.

Key Points

  • Older women show a significantly lower absolute lymphocyte count compared to younger women, indicating greater lymphopenia.
  • Mean absolute lymphocyte count at 6 months posttransplant was 0.59 K/µL in older women, lower than in younger women and older men.
  • Patients stratified by age and sex displayed varied immune responses, highlighting the importance of menopause status.
  • Cumulative infection risks were notably higher in postmenopausal women after organ transplantation, raising concerns for clinical management.

Cite This Study

Perry et al. (2025) studied this question.

synapsesocial.com/papers/68af540fad7bf08b1eadb055https://doi.org/10.1097/txd.0000000000001846
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Older Kidney Transplant Patients Are Over Immunosuppressed Using Standard Protocols With Differential Sex‐Based Complications2025 · 3 citations
  2. 2Sex Differences in Alloimmunity and Other Immunological Considerations in Organ Transplantation2026
  3. 3The effects of gender and age on health‐related quality of life following kidney transplantation2007 · 23 citations
  4. 4Older age is associated with a distinct and marked reduction of functionality of both alloreactive CD4+ and CD8+ T cells2024 · 2 citations
  5. 5Impact of Advanced Age on Posttransplant Infections and Outcomes in Solid Organ Transplant Recipients: A Multicenter Cohort Study2026