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May 8, 2026Transplant Infectious DiseaseOpen Access

Impact of Advanced Age on Posttransplant Infections and Outcomes in Solid Organ Transplant Recipients: A Multicenter Cohort Study

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Authors

STSibel Altunışık TopluVAVildan Avkan-OğuzETEsra Tanyel

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Overview

Retrospective cohort study evaluates infection effects and outcomes in transplant recipients by age group, suggesting monitoring needs.

Key Points

  • This study aims to evaluate the impact of advanced age on infection characteristics and clinical outcomes in solid organ transplant recipients.
  • Retrospective multicenter cohort study conducted at various transplant centers in Türkiye from 2003 to 2023.
  • Included 985 recipients, categorized into age groups: ≥ 60 years and < 60 years.
  • Compared demographic data, laboratory parameters, infection episodes, and clinical outcomes between age groups.
  • 273 (27.7%) patients were aged ≥ 60 years; longer hospital stays observed in this group (p = 0.002).
  • Similar incidence of infections between age groups; mortality rate in patients aged ≥ 60 years was 21.6%.
  • Bacterial infections were the most common cause of death, with a notable presence of carbapenem-resistant pathogens.

Cite This Study

Toplu et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e42bfa21ec5bbf067e2https://doi.org/10.1111/tid.70232
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal transplantation in older recipients – results of the DZIF transplant cohort2026
  2. 2Kidney Transplantation in Older Recipients: One-Year Outcomes and Complications from a Single-Center Experience2025 · 2 citations
  3. 3Infection Risk in Older Kidney Transplant Recipients: An Analysis in the Era of Expanded Age Limits2025
  4. 4Older Kidney Transplant Patients Are Over Immunosuppressed Using Standard Protocols With Differential Sex‐Based Complications2025 · 3 citations
  5. 5Biomarkers of biological aging in recipients of solid organ transplantation and clinical outcomes: A scoping review2023 · 1 citations