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Ester prodrugs improved anti-inflammatory activity and reduced ulcerogenic effects of NSAIDs, indicating safer pain relief options.
The ester prodrugs are for enhancing the anti-inflammatory activity and for reduction of ulcerogenic effects of NSAIDs. Also, the studies attempted to evaluate the pharmacokinetics of the prodrugs by in-vitro methods. The inflammation induced by carrageenan that is an acute model. The carriers used in research work, sesamol, umbelliferone and thymol, also produced anti-inflammatory activity and antioxidant effects. Therefore, overall, the synthesized products showed synergistic anti-inflammatory activity. The natural phenolic antioxidants for synthesizing the ester prodrugs are sesamol, 4- methyl umbelliferone and thymol and that itself showed various pharmacological activities.
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Kumar et al. (2025) studied this question.
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