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January 1, 2025RSC AdvancesOpen Access

Triarylpyrylium-based fluorescent DNA-binding dyes – facile synthesis, substituent effects, and sensing mechanism

Farkas Domahidy Levente Cseri Gábor Turczel Blanka Huszár Balázs Rózsa Zoltán Mucsi Ervin Kovács

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Key Points

The novel fluorescent dyes show enhanced DNA-binding capabilities, facilitating their use in biological applications.
Computational analysis reveals key insights into the mechanisms driving their fluorogenicity, emphasizing unique interactions with DNA.
The dyes were synthesized using a straightforward process, allowing for easy modification and testing of substituent effects.
This research highlights innovative approaches to fluorescent dye development, with potential implications in sensing technologies.

Implication

Novel fluorescent DNA-binding dyes exhibit unique properties, suggesting a promising application in sensing mechanisms.

Abstract

A series of novel fluorescent DNA-binding pyrylium dyes is developed, and the mechanism of their fluorogenicity is explored computationally.

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Cite This Study

Domahidy et al. (2025) studied this question.

synapsesocial.com/papers/68af55c6ad7bf08b1eadbb75 https://doi.org/10.1039/d5ra04750a

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