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August 22, 2025Open Access

Triple Actions of a Novel Polyherbal JDED Formulation Restores Glycemic and Reproductive Function in Diabetic Male Rats Via Antioxidant, Hormonal and Metabolomic Modulation

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Authors

CJChaitra JinkaUniversiti Malaysia TerengganuNZNor Hafizah ZakariaUniversiti Malaysia TerengganuFadzilah Adibah Abdul MajidFadzilah Adibah Abdul MajidUniversiti Malaysia Terengganu

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Implication

Observational analysis revealed improved glycemic and reproductive function in diabetic male rats, highlighting the potential of JDED in diabetes management.

Key Points

  • JDED treatment significantly reduced fasting blood glucose, restoring glycemic levels with marked hormonal improvements.
  • Key metrics showed an increase in antioxidant enzymes, with SOD and CAT levels rising by 1.77- and 6.5-fold, respectively.
  • Assessment via in vivo methods showed enhanced sperm motility and count, with improvements in testis and pancreas weights.
  • Findings indicate JDED's multi-targeted therapeutic effects via antioxidant, hormonal, and metabolic pathways.

Cite This Study

Jinka et al. (2025) studied this question.

synapsesocial.com/papers/68af55d1ad7bf08b1eadc4a7https://doi.org/10.21203/rs.3.rs-7422197/v1
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