April 9, 2025Open Access

Genetic Architectures and Molecular Interventions in Craniofacial Development: Paving the Way for Advanced Diagnostic and Therapeutic Frontiers

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Discussion

Narrative review highlights genetic factors affecting orthodontic outcomes, suggesting new therapeutic avenues.

Key transcription factors regulate embryonic craniofacial development, shaping orthodontic phenotypes.
Identification of over 90 genes linked to severe craniofacial malformations emphasizes a complex genetic basis.
Exploration of cranial neural crest cells reveals their significant influence on developing craniofacial structures.
The integration of genetic insights into orthodontics may lead to personalized diagnostics and innovative treatments.

Dragomirescu et al. (2025) studied this question.

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