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August 19, 2025PLoS GeneticsOpen Access

Transcriptomic landscape and chromatin accessibility uncover pivotal regulators driving programmed larval-larval molting in the domesticated silkworm

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Authors

YWYun WangSouthern University of Science and TechnologyXYXin YangMinistry of Agriculture and Rural AffairsJHJunfeng HongChongqing Normal University

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Overview

Study uncovers key regulators of gene expression and chromatin dynamics in silkworm molting, suggesting 20E plays a crucial role.

Key Points

  • Dynamic gene expression patterns were linked to hormonal fluctuations during the silkworm's molting cycle.
  • Chromatin footprint analysis revealed vital regulators like C/EBP and Fushi-tarazu f1 that control epidermal remodeling.
  • Epidermal-specific knockout of C/EBP and βFtz-f1 disrupted proteins necessary for forming new cuticles.
  • This research enhances understanding of how hormonal changes drive insect developmental processes.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af55dead7bf08b1eadca25https://doi.org/10.1371/journal.pgen.1011837
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  3. 3Single-cell and spatial transcriptomics define 20E-driven developmental reprogramming in silkworm wing disc2026 · 2 citations
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  5. 5BmMBNL Knockout Disrupts Molting of Silkworm, Bombyx mori, Through Inhibiting Expressions of Chitin Synthetase and Chitinase2026