Figure 6 from Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7–Expressing CRPC Models

XZ739 in combination with S63845 has synergistic antitumor effects in CRPC cell lines. A to I, CellTiter-Glo viability data from 2D cultures of LNCaP95, VCaP-CR, and 22Rv1 cell lines. Cell viability data for the dual treatment (A–C) were generated by CellTiter-Glo. Dose–response matrices (D–F) and Bliss synergy plots (G–I) were created using the SynergyFinder+ R package. J to M, 3D spheroid model and cell viability of LNCaP95 (J and K) and 22Rv1 cells (L and M). Data are presented as mean ± SD. **, P < 0.01; ****, P < 0.0001. All experiments were completed in triplicate. Spheroid images are representative of three replicates.