Objective: A bioflavonoid obtained from plants in the Moraceae family, morin exhibits strong pharmacological potential because of its hepatoprotective, neuroprotective, cardioprotective, anti-inflammatory, antioxidant, and anticancer effects. It is a promising therapeutic agent for diseases like diabetes, cancer, and neurodegenerative disorders because of its low toxicity and capacity to alter important cellular signaling pathways like Nrf2/HO-1 and EGFR. Data Sources: Its antioxidant mechanism effectively reduces oxygen species that are reactive and oxidative damage through the Nrf2/HO-1 pathway, potentially preventing neurodegenerative diseases. Study Selection: The effectiveness of morin has been proven in both Parkinson's disease and colitis models, highlighting its neuroprotective and anti-inflammatory properties, anti-oxidant, cardioprotective, anti-diabetic, synergistic effects. Morin's anti-inflammatory properties, whereby it reduces glial activation and improves tissue recovery. Summary of Contents of the Article: Morin acts as a non-competitive inhibitor of PTP1B in anti-diabetic studies, thereby enhancing insulin sensitivity. Its anti-cancer effects consist in increasing death by caspase activation and blocking of metastases in breast cancer. Morin also guards against liver damage, neurotoxicity, and myocardial ischemia-reperfusion injury. Conclusion: Although morin has low toxicity and great tolerance, the exact molecular mechanisms of it are yet unknown and demand more in vitro and in vivo research. Establishing safe dosage, efficacy, and dose-response relationships requires clinical trials, which also help to open the path for morin's inclusion into dietary supplements and drug development for chronic diseases. Keywords: Caspase activation, Flavonoid, Hepatoprotective, Morin, Reactive oxygen species.
Jain et al. (Fri,) studied this question.