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August 15, 2025AntibioticsOpen Access

Spontaneous Emergence of Cefiderocol Resistance in Klebsiella pneumoniae KPC-163: Genomic and Transcriptomic Insights

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Authors

ILIrene LuuVMVyanka MezcordJEJenny Escalante

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Overview

Genomic and transcriptomic insights reveal mechanisms behind cefiderocol resistance in CRKP strains, indicating therapeutic vulnerabilities.

Key Points

  • Cefiderocol resistance emerged spontaneously in a KPC-producing Klebsiella pneumoniae subpopulation, suggesting a critical adaptation process.
  • Downregulation of blaKPC-163 restored carbapenem sensitivity, highlighting potential collateral susceptibility in resistant strains.
  • Whole-genome sequencing identified mutations affecting iron uptake systems, correlating with the evolution of resistance in Klebsiella pneumoniae.
  • Enhanced oxidative stress responses suggest adaptive changes in resistance mechanisms, potentially guiding future therapeutic strategies.

Cite This Study

Luu et al. (2025) studied this question.

synapsesocial.com/papers/68af5701ad7bf08b1eadd7e2https://doi.org/10.3390/antibiotics14080832
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