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August 25, 2025Scientific ReportsOpen Access

Exploring mutational possibilities of KPC variants to reach high level resistance to cefiderocol

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Authors

SHS. HannaKLKévin LaYYYumi Yoshii

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Overview

Exploratory analysis identifies multiple mutations enhancing cefiderocol resistance in Klebsiella pneumoniae, suggesting ongoing risks.

Key Points

  • Elevated MICs for cefiderocol were observed in several KPC variants, indicating serious resistance risks.
  • Random mutagenesis followed by selection under cefiderocol pressure yielded resistant mutants exceeding 32 mg/L MICs.
  • Mutations affecting genes like cirA and ybiX indicate a multifactorial pathway to high-level resistance against cefiderocol.
  • Ongoing surveillance is crucial for detecting emerging cefiderocol resistance in KPC-producing Enterobacterales.

Cite This Study

Hanna et al. (2025) studied this question.

synapsesocial.com/papers/68af5f0dad7bf08b1eae1998https://doi.org/10.1038/s41598-025-17044-8
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