Rapid Synthesis of Indazole derivatives using Microwave Technology, its Characterisation and Anti-Inflammatory effects Observed in Laboratory Tests

In this study, we synthesized a range of indazole derivatives, including 1H-indazole and 4-chloro indazole, using microwave-assisted reactions. These reactions employed ortho-chlorobenzaldehyde, ortho-nitro benzaldehyde, and 2,6-dichlorobenzaldehyde as starting materials, all carried out in distilled water. This method proved to be faster and more efficient than conventional synthesis techniques. To verify the structures of the compounds, we employed various techniques to characterize the compounds, including melting point determination, thin layer chromatography (TLC), infrared spectroscopy (IR), nuclear magnetic resonance (NMR) spectroscopy, and Thin Layer Chromatography Mass Spectrometry (TLC-MS). Furthermore, these compounds exhibited significant anti-inflammatory activity, assessed by their ability to inhibit egg albumin denaturation. This microwave-assisted method offers an efficient and practical approach for synthesizing indazole derivatives, showing strong potential for anti-inflammatory applications.