Microwave-assisted Solvent-free Synthesis of Some New 4-[2-(Substituted phenyl)-4, 5-diphenyl-1H-imidazole-1-yl]-1H-indoles of Biological Interest

Solvent-free, microwave-assisted synthesis of several new indolyl imidazoles of biological importance is reported. First, indoleamine was condensed with substituted aryl aldehydes to give corresponding Schiff's bases. Then, Schiff's bases were reacted with ammonium acetate and benzil using silica gel as the solid support to yield the corresponding substituted indolyl imidazole derivatives. A comparison between the conventional approach and the microwave-assisted method is also reported in this research. All the synthesized substituted indolyl imidazole derivatives showed good antibacterial activity against Gram (-ve) bacterial strains (Escherichia coli and Klebsiella pneumonia). The synthesized indolyl imidazole derivatives also showed significant anticancer activity against the Dalton's lymphoma ascites cell line..