Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 22, 2025International Journal of Basic & Clinical PharmacologyOpen Access

A comparative analysis of fluoxetine and amitriptyline in depression: assessing effectiveness and adherence in a rural hospital setting

View Full Paper
Ask AI
Bookmark
Share

Authors

RDR. DhanalakshmiVellore Institute of Technology UniversityKAK ArunkumarGovernment Medical CollegeATAli TahmasebiIsfahan University of Medical Sciences

Discussion

Loading...

Member takes

Overview

Prospective analysis compares fluoxetine and amitriptyline effectiveness in newly diagnosed depression patients, highlighting adherence impact.

Key Points

  • Fluoxetine led to greater mean reduction in Hamilton depression rating scale scores than amitriptyline, enhancing treatment outcomes.
  • A statistically significant positive correlation between medication adherence and effectiveness was noted for both fluoxetine and amitriptyline.
  • This prospective observational study included 126 newly diagnosed depression patients over six months in a rural hospital setting.
  • Higher medication adherence was associated with better clinical outcomes, emphasizing its role in managing depression.

Cite This Study

Dhanalakshmi et al. (2025) studied this question.

synapsesocial.com/papers/68af59d7ad7bf08b1eade67ehttps://doi.org/10.18203/2319-2003.ijbcp20252577
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence1986 · 5,382 citations
  2. 2Prevalence and socioeconomic impact of depressive disorders in India: multisite population-based cross-sectional study2019 · 174 citations
  3. 3Prevalence and age patterns of depression in the United Kingdom. A population-based study2020 · 91 citations
  4. 4The relationship between gender, marital status and depression among Chinese middle-aged and older people: Mediation by subjective well-being and moderation by degree of digitization2022 · 54 citations
  5. 5Depression and Employment Status in Primary and Tertiary Care Settings2015 · 83 citations