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September 16, 2025European PsychiatryOpen Access

Effectiveness of Psychotherapy vs Antidepressants for Depression in Primary Care in India: A Randomized Pilot Trial

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Authors

JPJulia R PozueloALAvijit LahiriRSRahul Singh

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Overview

Randomized pilot trial evaluated treatment outcomes in primary care, suggesting both methods are effective.

Key Points

  • Both psychotherapy based on behavioral activation and fluoxetine significantly reduced depressive symptoms.
  • Average PHQ-9 score decreased from 15.02 to 6.73 after three months, indicating marked improvement.
  • High adherence observed, with 79% of participants completing their treatment protocol successfully.
  • Pilot trial demonstrated feasibility and acceptability for future larger studies on depression treatment.

Cite This Study

Pozuelo et al. (2025) studied this question.

synapsesocial.com/papers/68d4507d31b076d99fa57f9fhttps://doi.org/10.1192/j.eurpsy.2025.795
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