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August 22, 2025International Journal of Molecular SciencesOpen Access

Impact of Photobiomodulation on the Pro-Osteogenic Activity of Dental Pulp Mesenchymal Stem/Stromal Cells

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Authors

MFMarcella Rodrigues Ueda FernandesGTGabriella TetiVGValentina Gatta

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Overview

Experimental analysis shows photobiomodulation boosts osteogenic markers in dental pulp stem cells, indicating its regenerative potential.

Key Points

  • Photobiomodulation significantly improved mineral deposition and osteogenic marker expression in dental pulp stem cells, showing promise for regenerative dentistry.
  • The study revealed increased levels of IL-6 and IL-8 release, suggesting enhanced bone remodeling post-photobiomodulation treatment.
  • Cell viability remained high under tested photobiomodulation conditions, indicating a lack of toxicity.
  • Transmission electron microscopy highlighted cellular changes mainly in mitochondria and the endoplasmic reticulum during photobiomodulation application.

Cite This Study

Fernandes et al. (2025) studied this question.

synapsesocial.com/papers/68af59ddad7bf08b1eade775https://doi.org/10.3390/ijms26178174
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of photobiomodulation on human dental pulp stem cells treated with a bone xenograft: An in vitro study2026 · 1 citations
  2. 2Photobiomodulation and low-intensity pulsed ultrasound synergistically enhance dental mesenchymal stem cells viability, migration and differentiation: an invitro study2024 · 14 citations
  3. 3A Concise Review of the Impact of Photobiomodulation (PBM) on Neuronal Differentiation in Adipose-Derived Mesenchymal Stem Cells2026
  4. 4Osteoblastic differentiation and changes in the redox state in pulp stem cells by laser treatment2024 · 5 citations
  5. 5In vitro effect of simultaneous irradiation of 635 and 980 nm lasers on proliferation of periodontal ligament mesenchymal cells and their differentiation to osteoblasts2026