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August 15, 2025Advanced Functional Materials

Intracellular Delivery of CRISPR/Cas9 via Living Bacteria to Block Arginine Metabolic Reprogramming and Enhance Tumor Chemotherapy Sensitivity

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Authors

LALulu AnYLY. LiuZYZichen Yang

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Overview

This approach boosts chemotherapy sensitivity in tumors by targeting arginine metabolism, highlighting immune system activation.

Key Points

  • Tumor inhibition rate increased 3.2 times with engineered bacteria delivering CRISPR/Cas9 compared to DOX alone.
  • The engineered bacteria achieved 23.7-fold higher intracellular invasion efficiency, enhancing therapeutic effects.
  • CRISPR/Cas9 knockdown of the SLC7A2 gene improved chemotherapy responses in triple-negative breast cancer models.
  • This strategy demonstrates significant potential in overcoming metabolic resistance in chemotherapy for breast cancer.

Cite This Study

An et al. (2025) studied this question.

synapsesocial.com/papers/68af59e3ad7bf08b1eadeb84https://doi.org/10.1002/adfm.202504296
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