Novel multimodal analysis reveals pathogenic neutrophils in inflammation and liver cirrhosis patients, indicating significant insights into cellular phenotypes.
Multimodal single-cell approaches allow for a holistic analysis of complex biological systems. In this study, we developed a novel single-cell analysis pipeline integrating immunofluorescence-based protein with mass spectrometry imaging-based lipid analysis of circulating human neutrophils. The combination of both modalities identified the emergence of pathogenic neutrophils in liver cirrhosis patients thus epitomizing the potential of this technology to reveal cellular phenotypes in health and disease.
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Bessler et al. (2025) studied this question.
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