The phosphine-catalyzed 3 + 2 annulation yields spirocyclic structures in high yields, suggesting new pathways in organic synthesis.
This study presents a phosphine-catalyzed [3 + 2] annulation of sulfamidate imine-derived 1-azadienes with Morita–Baylis–Hillman (MBH) carbonates or allenoates, affording densely functionalized spiro[oxathiazole-cyclopentene] architectures under mild reaction conditions in generally high yields and excellent diastereoselectivities. Through a reductive ring contraction sequence of the spirocyclic thiosulfamide, valuable spirocyclic aziridine derivatives were accessed conveniently via both two-step and one-pot protocols.
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Wang et al. (2025) studied this question.
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