The research demonstrates how venom shelf life affects toxicity in mice, suggesting implications for understanding snake venom potency.
The presented article studies the lethal dose LD100 of the venom of the blunt-nosed viper (Macrovipera lebetina obtusa). This work aimed to identify the effect of the shelf life of the blunt-nosed viper venom on its toxicity. Venom samples with different shelf lives collected in 1989, 1993, 2010, and 2015 were used for the experiments. The experiments were conducted on 60 white outbred laboratory mice (males) weighing 18.0-22.0 g. As a result of experimental studies, it was found that the introduction of venom with different shelf lives to mice causes changes in the life expectancy of experimental animals compared to the control animals, which is manifested in a significant increase in their life expectancy from 28 to 90 minutes. It was found that with an increase in the shelf life of the venom, a decrease in the toxicity of the venom is noted, which leads to an increase in the life expectancy of the experimental mice. It has been experimentally revealed that with an increase in the shelf life of the poison, a decrease in the toxicity of the poison is noted, which leads to an increase in the life expectancy of the experimental mice. As a result of experimental studies, the lethal dose of the blunt-nosed viper venom LD50 of the studied samples with intraperitoneal administration to white mice was determined to be 3.0 mg/kg of body weight. The lethal dose LD100 of the studied samples of blunt-nosed viper venom was established, which (Macrovipera lebetina obtusa) corresponded to 6.0 mg/kg of body weight.
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TOPCHIYEVA et al. (2025) studied this question.
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