Comparative study reveals a significant decrease in total venom protein levels in Macrovipera lebetina obtusa, indicating implications for biological activity.
Animal toxins are a complex of natural biologically active compounds, but there are gaps in the comprehensive study of snake venoms, including in the study of the venom of the Transcaucasian viper. The purpose of the study is a comparative analysis of the total protein of the venom of viper (Macrovipera lebetina obtusa Linnaeus, 1758) with different storage periods. Protein concentrations were determined using the Bradford method. We conducted experiments to determine the total protein in samples of viper venom that were collected in 1989, 1991, 1993, 2010, 2015. As a result of experimental studies, a decrease in the total protein content of viper venom was revealed during long-term storage in the period from 1989 to 2015 and amounted to 55.0%, 59.8%, 73.6%, 83.4%, 93.0%, respectively. The results of the data obtained can be used in the identification, standardization and determination of the biological activity of both individual biologically active components of the Transcaucasian viper venom and drugs based on them.
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Sh. A. Topchiyeva (2024) studied this question.
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