Case report highlights surgical resection outcomes for IPMN and IPNB in a 58-year-old man, suggesting tailored management is critical.
BACKGROUND Intraductal papillary mucinous neoplasm (IPMN) and intraductal papillary neoplasm of the bile duct (IPNB) are mucinous cystic tumors with intraductal papillary growth and malignant potential. Their concurrent occurrence is exceptionally rare. CASE SUMMARY A 58-year-old Chinese man presented with recurrent upper abdominal pain. Imaging and laboratory tests revealed lesions consistent with IPNB and IPMN. Postoperative pathological examination confirmed IPNB with high-grade dysplasia and main-duct type IPMN with low-grade dysplasia. The patient underwent extrahepatic bile duct resection with Roux-en-Y choledochoenterostomy and distal pancreatectomy. He had an excellent prognosis with no tumor recurrence during the 30-month follow-up. CONCLUSION This case emphasizes the importance of comprehensive preoperative assessment and individualized management for these complex tumors. Further research is needed to understand their pathogenesis and improve treatment strategies.
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Huang et al. (2025) studied this question.
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