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August 24, 2025CureusOpen Access

A Comparison of Piperacillin-Tazobactam With Conventional Antibiotics for Prophylaxis in Lower Extremity Type III Open Fractures

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Authors

APAnthony V. PaternoUniversity of North Carolina at Chapel Hill ANAlysa NashDepartment of Fisheries BLBradley J. LauckUniversity of North Carolina at Chapel Hill

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Implication

Retrospective analysis reveals no difference in SSIs using piperacillin-tazobactam or conventional antibiotics in type III open fractures, implying potential safety benefits.

Key Points

No significant difference in surgical site infections was observed among antibiotic regimens used in type III open fractures.
Thirty-seven patients treated with piperacillin-tazobactam, cefazolin plus gentamicin, or cefazolin plus gentamicin plus tobramycin showed similar SSI rates.
This retrospective analysis at a level one trauma center analyzed outcomes across three antibiotic protocols for 164 patients.
Findings suggest piperacillin-tazobactam may be as effective as traditional regimens with fewer adverse effects for trauma patients.

Cite This Study

Paterno et al. (2025) studied this question.

synapsesocial.com/papers/68af5bc1ad7bf08b1eadfc5f https://doi.org/10.7759/cureus.90890

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Implication

Retrospective analysis reveals no difference in SSIs using piperacillin-tazobactam or conventional antibiotics in type III open fractures, implying potential safety benefits.

A Comparison of Piperacillin-Tazobactam With Conventional Antibiotics for Prophylaxis in Lower Extremity Type III Open Fractures

Discussion

Member takes

Implication

Key Points

Cite This Study

A Comparison of Piperacillin-Tazobactam With Conventional Antibiotics for Prophylaxis in Lower Extremity Type III Open Fractures

Discussion

Member takes

Implication

Key Points

Cite This Study

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