What question did this study set out to answer?

The aim was to compare the effectiveness of ceftriaxone versus cefazolin-based protocols for preventing infections in open fractures.

Single Antibiotic Use with Ceftriaxone for Prophylaxis of All Open Fractures

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Retrospective cohort study compares ceftriaxone outcomes for open fractures, indicating effective prophylaxis.

The aim was to compare the effectiveness of ceftriaxone versus cefazolin-based protocols for preventing infections in open fractures.
Retrospective cohort study including adult patients with open fractures from December 2016 to December 2022.
Comparison of deep infection, superficial infection, nonunion, and time to antibiotic administration between two treatment groups (CTX and Classic).
Data analysis involved patient outcomes based on Gustilo fracture types.
Deep infection rates for ceftriaxone were 7.8% compared to 12.7% for cefazolin, p=0.095, demonstrating non-inferiority for all Gustilo types.
The CTX protocol showed a significantly shorter time to antibiotic administration (63.9 minutes vs 114.1 minutes, p=0.002).
No significant differences in rates of superficial infection or nonunion were observed.

Koulopoulos et al. (2026) studied this question.

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