What type of study is this?

This is a Systematic Review study.

August 24, 2025DiagnosticsOpen Access

From Subtle Signs to Severe Sequelae—A Century of Symptomatology and Comorbidities in the Diagnosis of GH-Secreting Pituitary Neuroendocrine Tumors: A Systematic Review

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Timely recognition of symptoms can prevent irreversible physical changes and complications.
Enlarged extremities and facial changes were the most common signs, reported in 12.4% and 13.1% of patients, respectively.
Observational analysis of 93 studies covering 1745 patients showed significant comorbidities related to GH-secreting tumors.
Awareness of symptoms is vital for early diagnosis to reduce the average 6.7-year diagnostic delay and improve patient outcomes.

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Systematic review reveals common symptoms and prevalent comorbidities in patients with GH-secreting tumors, emphasizing timely diagnosis.

Pérez et al. (2025) studied this question.

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