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This is a Observational study (also classified as: In Vitro Study).

August 23, 2025DiagnosticsOpen Access

Genomic Insights into Tumorigenesis in Newly Diagnosed Multiple Myeloma

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This research uncovers somatic and germline mutations in multiple myeloma, highlighting genetic transitions contributing to tumorigenesis.

Frequent germline and somatic mutations were identified, emphasizing their role in tumorigenesis and cancer progression.
Key mutations were found in genes such as HLA-A, HLA-B, and KIF, indicating significant implications for disease mechanisms.
Analysis utilized a computational pipeline on single-cell RNA-sequencing, enhancing the detection of genetic changes across disease stages.
Understanding these mutations may improve early detection and guide personalized therapies for multiple myeloma patients.

Kyriakou et al. (2025) studied this question.

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August 23, 2025DiagnosticsOpen Access

View Full Paper

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Authors

This research uncovers somatic and germline mutations in multiple myeloma, highlighting genetic transitions contributing to tumorigenesis.

Frequent germline and somatic mutations were identified, emphasizing their role in tumorigenesis and cancer progression.
Key mutations were found in genes such as HLA-A, HLA-B, and KIF, indicating significant implications for disease mechanisms.
Analysis utilized a computational pipeline on single-cell RNA-sequencing, enhancing the detection of genetic changes across disease stages.
Understanding these mutations may improve early detection and guide personalized therapies for multiple myeloma patients.

Kyriakou et al. (2025) studied this question.

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